Buy MGF (Mechano Growth Factor) Research Peptide

What is MGF (Mechano Growth Factor)?

Mechano Growth Factor (MGF) is a version of IGF-1 the body makes locally in muscle in response to mechanical stress such as exercise or injury. It acts right at the stressed spot and is studied in animal research for its effects on muscle repair cells.

• A local splice variant of IGF-1 made in muscle under mechanical stress
• Studied for its effects on muscle satellite (repair) cells at the site of stress
• Acts locally and differs from whole-body IGF-1 in how it binds and works
• Studied in animal research on muscle responses to stress and injury

For research use only. Not approved for human therapeutic use.

MGF (Mechano Growth Factor), also known as IGF-1 Ec, is a synthetic 24-amino acid peptide corresponding to the C-terminal E-domain of the insulin-like growth factor 1 Ec splice variant. With the molecular formula C121H200N42O39 and a molecular weight of 2867.26 g/mol, MGF is defined by the amino acid sequence Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys. In native physiology this peptide domain is generated by alternative splicing of the IGF-1 gene and is expressed in a mechano-sensitive manner following tissue strain. Produced via solid-phase peptide synthesis, Mechano Growth Factor is associated with IGF-1 receptor-related signalling pathways in preclinical research.

MGF has been extensively investigated in preclinical growth factor research as the isolated E-domain peptide of the IGF-1 Ec isoform. Unlike mature IGF-1 which consists of the 70-amino acid core protein, Mechano Growth Factor represents the splice-specific C-terminal extension characterised in published studies for its independent signalling properties. In vitro studies in C2C12 myoblast and satellite cell-derived preparations have examined MGF’s interaction with skeletal muscle-derived cell populations, documenting differential roles of the Ec E-peptide relative to mature IGF-1 in myoblast proliferation kinetics and differentiation timing [1]. Rodent model studies have examined the relationship between E-domain peptide presence and downstream cellular responses in skeletal muscle and neural tissue preparations, documenting differential activity across IGF-1 splice variants including the Ec isoform under controlled preclinical conditions [2], making Mechano Growth Factor a key reference compound in IGF-1 splice variant research across skeletal muscle and neural tissue models.

MGF is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

References

1Yang SY, Goldspink G. Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation. FEBS Lett. 2002 Jul 3;522(1–3):156–60. .PubMed PMID: 120956372Aperghis M, Johnson IP, Cannon J, Yang SY, Goldspink G. Different levels of neuroprotection by two insulin-like growth factor-I splice variants. Brain Res. 2004 May 29;1009(1–2):213–8. .PubMed PMID: 15120599

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

View credentials →

MGF (Mechano Growth Factor), also known as IGF-1 Ec, is a synthetic 24-amino acid peptide corresponding to the C-terminal E-domain of the insulin-like growth factor 1 Ec splice variant. With the molecular formula C121H200N42O39 and a molecular weight of 2867.26 g/mol, MGF is defined by the amino acid sequence Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys. In native physiology this peptide domain is generated by alternative splicing of the IGF-1 gene and is expressed in a mechano-sensitive manner following tissue strain. Produced via solid-phase peptide synthesis, Mechano Growth Factor is associated with IGF-1 receptor-related signalling pathways in preclinical research.

MGF has been extensively investigated in preclinical growth factor research as the isolated E-domain peptide of the IGF-1 Ec isoform. Unlike mature IGF-1 which consists of the 70-amino acid core protein, Mechano Growth Factor represents the splice-specific C-terminal extension characterised in published studies for its independent signalling properties. In vitro studies in C2C12 myoblast and satellite cell-derived preparations have examined MGF’s interaction with skeletal muscle-derived cell populations, documenting differential roles of the Ec E-peptide relative to mature IGF-1 in myoblast proliferation kinetics and differentiation timing [1]. Rodent model studies have examined the relationship between E-domain peptide presence and downstream cellular responses in skeletal muscle and neural tissue preparations, documenting differential activity across IGF-1 splice variants including the Ec isoform under controlled preclinical conditions [2], making Mechano Growth Factor a key reference compound in IGF-1 splice variant research across skeletal muscle and neural tissue models.

MGF is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

References

1Yang SY, Goldspink G. Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation. FEBS Lett. 2002 Jul 3;522(1–3):156–60. .PubMed PMID: 120956372Aperghis M, Johnson IP, Cannon J, Yang SY, Goldspink G. Different levels of neuroprotection by two insulin-like growth factor-I splice variants. Brain Res. 2004 May 29;1009(1–2):213–8. .PubMed PMID: 15120599

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

View credentials →CAS Number162809-23-6Molecular Weight2,867.16 g/molPurity≥98%Physical FormLyophilised PowderManufacturingManufactured in an ISO9001 Certified LaboratoryTestingHPLC + MS-UPLCSKUMGF

Lyophilised powder: store at -20 °C or below, away from light and moisture. Once reconstituted in an appropriate laboratory diluent (e.g. sterile water, PBS, or assay buffer), store at 2–8 °C and use within the validated period for your protocol. Do not refreeze.

MGF (Mechano Growth Factor), also known as IGF-1 Ec, is a synthetic 24-amino acid peptide corresponding to the C-terminal E-domain of the insulin-like growth factor 1 Ec splice variant. With the molecular formula C121H200N42O39 and a molecular weight of 2867.26 g/mol, MGF is defined by the amino acid sequence Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys. In native physiology this peptide domain is generated by alternative splicing of the IGF-1 gene and is expressed in a mechano-sensitive manner following tissue strain. Produced via solid-phase peptide synthesis, Mechano Growth Factor is associated with IGF-1 receptor-related signalling pathways in preclinical research.

MGF has been extensively investigated in preclinical growth factor research as the isolated E-domain peptide of the IGF-1 Ec isoform. Unlike mature IGF-1 which consists of the 70-amino acid core protein, Mechano Growth Factor represents the splice-specific C-terminal extension characterised in published studies for its independent signalling properties. In vitro studies in C2C12 myoblast and satellite cell-derived preparations have examined MGF’s interaction with skeletal muscle-derived cell populations, documenting differential roles of the Ec E-peptide relative to mature IGF-1 in myoblast proliferation kinetics and differentiation timing [1]. Rodent model studies have examined the relationship between E-domain peptide presence and downstream cellular responses in skeletal muscle and neural tissue preparations, documenting differential activity across IGF-1 splice variants including the Ec isoform under controlled preclinical conditions [2], making Mechano Growth Factor a key reference compound in IGF-1 splice variant research across skeletal muscle and neural tissue models.

MGF is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

References

1Yang SY, Goldspink G. Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation. FEBS Lett. 2002 Jul 3;522(1–3):156–60. .PubMed PMID: 120956372Aperghis M, Johnson IP, Cannon J, Yang SY, Goldspink G. Different levels of neuroprotection by two insulin-like growth factor-I splice variants. Brain Res. 2004 May 29;1009(1–2):213–8. .PubMed PMID: 15120599

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

View credentials →CAS Number162809-23-6Molecular Weight2,867.16 g/molPurity≥98%Physical FormLyophilised PowderManufacturingManufactured in an ISO9001 Certified LaboratoryTestingHPLC + MS-UPLCSKUMGF

Lyophilised powder: store at -20 °C or below, away from light and moisture. Once reconstituted in an appropriate laboratory diluent (e.g. sterile water, PBS, or assay buffer), store at 2–8 °C and use within the validated period for your protocol. Do not refreeze.