Buy Crystagen Research Peptide

What is Crystagen?

Crystagen is a short peptide from the Russian bioregulator research program, part of the same family as Epithalon and Vilon. It is studied in animal research for its effects on bone-marrow and immune-cell signaling.

• A short peptide studied for its effects on bone-marrow and immune-system tissue
• Part of the Russian organ-targeted bioregulator research program
• Studied in animal research for its effects on immune-cell signaling
• Investigated alongside Epithalon and Vilon from the same program

For research use only. Not approved for human therapeutic use.

Crystagen is a synthetic tripeptide bioregulator with the sequence Glu-Asp-Pro (EDP), corresponding to the molecular formula C₁₄H₂₁N₃O₈ and a free-acid molecular weight of approximately 359.33 g/mol. It belongs to the Khavinson family of ultrashort peptide bioregulators developed at the Saint Petersburg Institute of Bioregulation and Gerontology. EDP is one of the active short-peptide constituents of the thymus-derived polypeptide complex Thymalin. Produced via solid-phase peptide synthesis, Crystagen is classified as an immune-system (thymic) bioregulator.

In preclinical research models, Crystagen is studied for its capacity to modulate immune-cell activity. The immunomodulatory profile of the thymic complex to which EDP belongs has been directly characterised in vitro: in the human THP-1 monocyte/macrophage line, Thymalin and related Khavinson thymic peptides modulated proliferative activity and inflammatory cytokine pathways, consistent with a regulatory (rather than purely stimulatory) action on innate immune cells [1]. At the mechanistic level, and consistent with the proposed direct-to-DNA mode of action, fluorescently labelled peptides of this ultrashort class penetrate the cell nucleus and bind genomic DNA in a sequence-selective manner, providing a structural basis for peptide-directed modulation of tissue-specific gene expression [2]. Within the immune compartment, EDP-type thymic peptides are studied for effects on thymocyte differentiation and proliferation and on macrophage cytokine output, including in aged models where thymic involution is examined, making Crystagen a reference compound in preclinical immunology research examining thymic function, macrophage activation, and age-related immune decline.

Crystagen is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

References

1Avolio F, Martinotti S, Khavinson VK, Esposito JE, Giambuzzi G, Marino A, et al. Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line. Int J Mol Sci. 2022 Mar 25;23(7):3607. ; PubMed Central PMCID: PMC8999041.PubMed PMID: 354089632Fedoreyeva LI, Kireev II, Khavinson VK, Vanyushin BF. Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA. Biochemistry (Mosc). 2011 Nov;76(11):1210–9. .PubMed PMID: 22117547

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

View credentials →

Crystagen is a synthetic tripeptide bioregulator with the sequence Glu-Asp-Pro (EDP), corresponding to the molecular formula C₁₄H₂₁N₃O₈ and a free-acid molecular weight of approximately 359.33 g/mol. It belongs to the Khavinson family of ultrashort peptide bioregulators developed at the Saint Petersburg Institute of Bioregulation and Gerontology. EDP is one of the active short-peptide constituents of the thymus-derived polypeptide complex Thymalin. Produced via solid-phase peptide synthesis, Crystagen is classified as an immune-system (thymic) bioregulator.

In preclinical research models, Crystagen is studied for its capacity to modulate immune-cell activity. The immunomodulatory profile of the thymic complex to which EDP belongs has been directly characterised in vitro: in the human THP-1 monocyte/macrophage line, Thymalin and related Khavinson thymic peptides modulated proliferative activity and inflammatory cytokine pathways, consistent with a regulatory (rather than purely stimulatory) action on innate immune cells [1]. At the mechanistic level, and consistent with the proposed direct-to-DNA mode of action, fluorescently labelled peptides of this ultrashort class penetrate the cell nucleus and bind genomic DNA in a sequence-selective manner, providing a structural basis for peptide-directed modulation of tissue-specific gene expression [2]. Within the immune compartment, EDP-type thymic peptides are studied for effects on thymocyte differentiation and proliferation and on macrophage cytokine output, including in aged models where thymic involution is examined, making Crystagen a reference compound in preclinical immunology research examining thymic function, macrophage activation, and age-related immune decline.

Crystagen is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

References

1Avolio F, Martinotti S, Khavinson VK, Esposito JE, Giambuzzi G, Marino A, et al. Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line. Int J Mol Sci. 2022 Mar 25;23(7):3607. ; PubMed Central PMCID: PMC8999041.PubMed PMID: 354089632Fedoreyeva LI, Kireev II, Khavinson VK, Vanyushin BF. Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA. Biochemistry (Mosc). 2011 Nov;76(11):1210–9. .PubMed PMID: 22117547

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

View credentials →CAS NumberN/A (Khavinson bioregulator)Molecular Weight359.33 g/molPurity≥98%Physical FormLyophilised PowderManufacturingManufactured in an ISO9001 Certified LaboratoryTestingHPLC + MS-UPLCSKURSC-CRYSTAGEN-8754

Lyophilised powder: store at -20 °C or below, away from light and moisture. Once reconstituted in an appropriate laboratory diluent (e.g. sterile water, PBS, or assay buffer), store at 2–8 °C and use within the validated period for your protocol. Do not refreeze.

Crystagen is a synthetic tripeptide bioregulator with the sequence Glu-Asp-Pro (EDP), corresponding to the molecular formula C₁₄H₂₁N₃O₈ and a free-acid molecular weight of approximately 359.33 g/mol. It belongs to the Khavinson family of ultrashort peptide bioregulators developed at the Saint Petersburg Institute of Bioregulation and Gerontology. EDP is one of the active short-peptide constituents of the thymus-derived polypeptide complex Thymalin. Produced via solid-phase peptide synthesis, Crystagen is classified as an immune-system (thymic) bioregulator.

In preclinical research models, Crystagen is studied for its capacity to modulate immune-cell activity. The immunomodulatory profile of the thymic complex to which EDP belongs has been directly characterised in vitro: in the human THP-1 monocyte/macrophage line, Thymalin and related Khavinson thymic peptides modulated proliferative activity and inflammatory cytokine pathways, consistent with a regulatory (rather than purely stimulatory) action on innate immune cells [1]. At the mechanistic level, and consistent with the proposed direct-to-DNA mode of action, fluorescently labelled peptides of this ultrashort class penetrate the cell nucleus and bind genomic DNA in a sequence-selective manner, providing a structural basis for peptide-directed modulation of tissue-specific gene expression [2]. Within the immune compartment, EDP-type thymic peptides are studied for effects on thymocyte differentiation and proliferation and on macrophage cytokine output, including in aged models where thymic involution is examined, making Crystagen a reference compound in preclinical immunology research examining thymic function, macrophage activation, and age-related immune decline.

Crystagen is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

References

1Avolio F, Martinotti S, Khavinson VK, Esposito JE, Giambuzzi G, Marino A, et al. Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line. Int J Mol Sci. 2022 Mar 25;23(7):3607. ; PubMed Central PMCID: PMC8999041.PubMed PMID: 354089632Fedoreyeva LI, Kireev II, Khavinson VK, Vanyushin BF. Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA. Biochemistry (Mosc). 2011 Nov;76(11):1210–9. .PubMed PMID: 22117547

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

View credentials →CAS NumberN/A (Khavinson bioregulator)Molecular Weight359.33 g/molPurity≥98%Physical FormLyophilised PowderManufacturingManufactured in an ISO9001 Certified LaboratoryTestingHPLC + MS-UPLCSKURSC-CRYSTAGEN-8754

Lyophilised powder: store at -20 °C or below, away from light and moisture. Once reconstituted in an appropriate laboratory diluent (e.g. sterile water, PBS, or assay buffer), store at 2–8 °C and use within the validated period for your protocol. Do not refreeze.