Buy Pinealon Research Peptide

What is Pinealon?

Pinealon is a synthetic three-amino-acid peptide (Glu-Asp-Arg) from the Russian bioregulator program, designed to target brain tissue. It is studied in animal research for its effects on brain-cell protection and the body clock.

• A short peptide studied for its effects on brain tissue
• Part of the Russian organ-targeted bioregulator research program
• Studied in animal research for antioxidant activity and brain-cell protection
• Investigated for its effects on body-clock (circadian) signaling via the pineal gland

For research use only. Not approved for human therapeutic use.

Pinealon (CAS 175175-23-2), also known as EDR peptide, is a synthetic tripeptide bioregulator with the molecular formula C15H26N6O8 and a molecular weight of 418.41 g/mol. Defined by the amino acid sequence Glu-Asp-Arg, Pinealon belongs to the class of ultra-short peptide bioregulators developed at the Saint Petersburg Institute of Bioregulation and Gerontology. Its low molecular weight and amphiphilic character, combining hydrophilic acidic residues with a basic arginine residue, are considered relevant to its capacity to cross cellular membranes. Produced via solid-phase peptide synthesis.

Pinealon has been shown capable of penetrating cell membranes and the nuclear envelope. In vitro studies using fluorescein isothiocyanate-labelled peptide preparations characterised nuclear accumulation of Pinealon in HeLa cell cytoplasm, nucleus, and nucleolus, and showed sequence-specific interactions between the Glu-Asp-Arg tripeptide and deoxyribooligonucleotides and genomic DNA within the nuclear compartment, establishing nuclear penetration and DNA sequence recognition as primary in vitro properties of the EDR tripeptide [1]. In vivo rodent studies have investigated the compound in experimental models of prenatal and postnatal neurodevelopment, with research documenting that Pinealon administration in a prenatal hyperhomocysteinemia model documented changes in offspring spatial orientation and learning assessment scores assessed by Morris water maze, and reduced reactive oxygen species accumulation and necrotic cell count in cerebellum neurons isolated from offspring, characterising Pinealon as a neuroprotective agent against prenatal metabolic-stress-induced impairment of postnatal neurological and cognitive parameters [2], making Pinealon a reference compound in peptide bioregulator research examining nuclear-penetrating ultra-short tripeptides in the context of CNS gene expression and prenatal neuroprotection models.

Pinealon is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

References

1Fedoreyeva LI, Kireev II, Khavinson VK, Vanyushin BF. Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA. Biochemistry (Mosc). 2011 Nov;76(11):1210–9. .PubMed PMID: 221175472Arutjunyan A, Kozina L, Stvolinskiy S, Bulygina Y, Mashkina A, Khavinson V. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia. Int J Clin Exp Med. 2012 Apr 6;5(2):179–85. ; PubMed Central PMCID: PMC3342713.PubMed PMID: 22567179

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

View credentials →

Pinealon (CAS 175175-23-2), also known as EDR peptide, is a synthetic tripeptide bioregulator with the molecular formula C15H26N6O8 and a molecular weight of 418.41 g/mol. Defined by the amino acid sequence Glu-Asp-Arg, Pinealon belongs to the class of ultra-short peptide bioregulators developed at the Saint Petersburg Institute of Bioregulation and Gerontology. Its low molecular weight and amphiphilic character, combining hydrophilic acidic residues with a basic arginine residue, are considered relevant to its capacity to cross cellular membranes. Produced via solid-phase peptide synthesis.

Pinealon has been shown capable of penetrating cell membranes and the nuclear envelope. In vitro studies using fluorescein isothiocyanate-labelled peptide preparations characterised nuclear accumulation of Pinealon in HeLa cell cytoplasm, nucleus, and nucleolus, and showed sequence-specific interactions between the Glu-Asp-Arg tripeptide and deoxyribooligonucleotides and genomic DNA within the nuclear compartment, establishing nuclear penetration and DNA sequence recognition as primary in vitro properties of the EDR tripeptide [1]. In vivo rodent studies have investigated the compound in experimental models of prenatal and postnatal neurodevelopment, with research documenting that Pinealon administration in a prenatal hyperhomocysteinemia model documented changes in offspring spatial orientation and learning assessment scores assessed by Morris water maze, and reduced reactive oxygen species accumulation and necrotic cell count in cerebellum neurons isolated from offspring, characterising Pinealon as a neuroprotective agent against prenatal metabolic-stress-induced impairment of postnatal neurological and cognitive parameters [2], making Pinealon a reference compound in peptide bioregulator research examining nuclear-penetrating ultra-short tripeptides in the context of CNS gene expression and prenatal neuroprotection models.

Pinealon is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

References

1Fedoreyeva LI, Kireev II, Khavinson VK, Vanyushin BF. Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA. Biochemistry (Mosc). 2011 Nov;76(11):1210–9. .PubMed PMID: 221175472Arutjunyan A, Kozina L, Stvolinskiy S, Bulygina Y, Mashkina A, Khavinson V. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia. Int J Clin Exp Med. 2012 Apr 6;5(2):179–85. ; PubMed Central PMCID: PMC3342713.PubMed PMID: 22567179

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

View credentials →CAS Number175175-23-2Molecular Weight418.41 g/molPurity≥98%Physical FormLyophilised PowderManufacturingManufactured in an ISO9001 Certified LaboratoryTestingHPLC + MS-UPLCSKUPINE

Lyophilised powder: store at -20 °C or below, away from light and moisture. Once reconstituted in an appropriate laboratory diluent (e.g. sterile water, PBS, or assay buffer), store at 2–8 °C and use within the validated period for your protocol. Do not refreeze.

Pinealon (CAS 175175-23-2), also known as EDR peptide, is a synthetic tripeptide bioregulator with the molecular formula C15H26N6O8 and a molecular weight of 418.41 g/mol. Defined by the amino acid sequence Glu-Asp-Arg, Pinealon belongs to the class of ultra-short peptide bioregulators developed at the Saint Petersburg Institute of Bioregulation and Gerontology. Its low molecular weight and amphiphilic character, combining hydrophilic acidic residues with a basic arginine residue, are considered relevant to its capacity to cross cellular membranes. Produced via solid-phase peptide synthesis.

Pinealon has been shown capable of penetrating cell membranes and the nuclear envelope. In vitro studies using fluorescein isothiocyanate-labelled peptide preparations characterised nuclear accumulation of Pinealon in HeLa cell cytoplasm, nucleus, and nucleolus, and showed sequence-specific interactions between the Glu-Asp-Arg tripeptide and deoxyribooligonucleotides and genomic DNA within the nuclear compartment, establishing nuclear penetration and DNA sequence recognition as primary in vitro properties of the EDR tripeptide [1]. In vivo rodent studies have investigated the compound in experimental models of prenatal and postnatal neurodevelopment, with research documenting that Pinealon administration in a prenatal hyperhomocysteinemia model documented changes in offspring spatial orientation and learning assessment scores assessed by Morris water maze, and reduced reactive oxygen species accumulation and necrotic cell count in cerebellum neurons isolated from offspring, characterising Pinealon as a neuroprotective agent against prenatal metabolic-stress-induced impairment of postnatal neurological and cognitive parameters [2], making Pinealon a reference compound in peptide bioregulator research examining nuclear-penetrating ultra-short tripeptides in the context of CNS gene expression and prenatal neuroprotection models.

Pinealon is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

References

1Fedoreyeva LI, Kireev II, Khavinson VK, Vanyushin BF. Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA. Biochemistry (Mosc). 2011 Nov;76(11):1210–9. .PubMed PMID: 221175472Arutjunyan A, Kozina L, Stvolinskiy S, Bulygina Y, Mashkina A, Khavinson V. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia. Int J Clin Exp Med. 2012 Apr 6;5(2):179–85. ; PubMed Central PMCID: PMC3342713.PubMed PMID: 22567179

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

View credentials →CAS Number175175-23-2Molecular Weight418.41 g/molPurity≥98%Physical FormLyophilised PowderManufacturingManufactured in an ISO9001 Certified LaboratoryTestingHPLC + MS-UPLCSKUPINE

Lyophilised powder: store at -20 °C or below, away from light and moisture. Once reconstituted in an appropriate laboratory diluent (e.g. sterile water, PBS, or assay buffer), store at 2–8 °C and use within the validated period for your protocol. Do not refreeze.