Buy Matrixyl Research Peptide

What is Matrixyl?

Matrixyl is the trade name for palmitoyl pentapeptide-4, a synthetic skincare peptide. It is studied in skin-cell research for its effects on collagen production and the skin’s support scaffold, and is one of the most studied peptides in cosmetic research.

• A fatty-acid-tagged peptide designed to reach the lower skin layers
• Studied in skin-cell research for its effects on collagen and fibronectin
• The fatty-acid tag is studied for how it helps the peptide penetrate skin
• One of the most studied active ingredients in cosmetic peptide research

For research use only. Not approved for human therapeutic use.

Matrixyl (CAS 214047-00-4), also known as Palmitoyl Pentapeptide-4 or Pal-KTTKS, is a synthetic lipopeptide with a molecular weight of 802.06 g/mol. Its structure consists of the pentapeptide sequence Lys-Thr-Thr-Lys-Ser, corresponding to a fragment of type I procollagen, conjugated to a palmitoyl (C16 fatty acid) chain at the N-terminus. The KTTKS sequence was identified through systematic screening of procollagen-derived peptide fragments as a matrikine, a small peptide derived from extracellular matrix proteins that signals back to cells to modulate matrix biology. Produced via solid-phase peptide synthesis with subsequent N-terminal palmitoylation, Matrixyl is associated with collagen biosynthesis and dermal matrix remodelling pathways in preclinical dermatological research.

Matrixyl is one of the most studied matrikine-based lipopeptides in preclinical and cosmeceutical dermatology research. In vitro studies have documented that the parent KTTKS pentapeptide stimulates the production of collagen (types I and III) and fibronectin in cultured fibroblasts, establishing the sequence as a matrikine signal for extracellular matrix synthesis [1]. Structure-activity research has examined the role of the palmitoyl chain in cellular interaction and the contribution of the lipid modification to the compound’s observed activity in cell culture models, documenting that the palmitoylated peptide amphiphile C16-KTTKS self-assembles into nanotape structures and stimulates collagen synthesis in human dermal fibroblast culture, characterising the lipid-conjugated form of the KTTKS matrikine as the basis for its activity as a topically relevant peptide active [2], making Matrixyl a key reference compound in dermatological and extracellular-matrix research examining lipid-conjugated matrikine peptides and procollagen-derived signal sequences in preclinical models.

Matrixyl is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

References

1Katayama K, Armendariz-Borunda J, Raghow R, Kang AH, Seyer JM. A pentapeptide from type I procollagen promotes extracellular matrix production. J Biol Chem. 1993 May 15;268(14):9941–4. .PubMed PMID: 84867212Jones RR, Castelletto V, Connon CJ, Hamley IW. Collagen stimulating effect of peptide amphiphile C16-KTTKS on human fibroblasts. Mol Pharm. 2013 Mar 4;10(3):1063–9. .PubMed PMID: 23320752

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

View credentials →

Matrixyl (CAS 214047-00-4), also known as Palmitoyl Pentapeptide-4 or Pal-KTTKS, is a synthetic lipopeptide with a molecular weight of 802.06 g/mol. Its structure consists of the pentapeptide sequence Lys-Thr-Thr-Lys-Ser, corresponding to a fragment of type I procollagen, conjugated to a palmitoyl (C16 fatty acid) chain at the N-terminus. The KTTKS sequence was identified through systematic screening of procollagen-derived peptide fragments as a matrikine, a small peptide derived from extracellular matrix proteins that signals back to cells to modulate matrix biology. Produced via solid-phase peptide synthesis with subsequent N-terminal palmitoylation, Matrixyl is associated with collagen biosynthesis and dermal matrix remodelling pathways in preclinical dermatological research.

Matrixyl is one of the most studied matrikine-based lipopeptides in preclinical and cosmeceutical dermatology research. In vitro studies have documented that the parent KTTKS pentapeptide stimulates the production of collagen (types I and III) and fibronectin in cultured fibroblasts, establishing the sequence as a matrikine signal for extracellular matrix synthesis [1]. Structure-activity research has examined the role of the palmitoyl chain in cellular interaction and the contribution of the lipid modification to the compound’s observed activity in cell culture models, documenting that the palmitoylated peptide amphiphile C16-KTTKS self-assembles into nanotape structures and stimulates collagen synthesis in human dermal fibroblast culture, characterising the lipid-conjugated form of the KTTKS matrikine as the basis for its activity as a topically relevant peptide active [2], making Matrixyl a key reference compound in dermatological and extracellular-matrix research examining lipid-conjugated matrikine peptides and procollagen-derived signal sequences in preclinical models.

Matrixyl is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

References

1Katayama K, Armendariz-Borunda J, Raghow R, Kang AH, Seyer JM. A pentapeptide from type I procollagen promotes extracellular matrix production. J Biol Chem. 1993 May 15;268(14):9941–4. .PubMed PMID: 84867212Jones RR, Castelletto V, Connon CJ, Hamley IW. Collagen stimulating effect of peptide amphiphile C16-KTTKS on human fibroblasts. Mol Pharm. 2013 Mar 4;10(3):1063–9. .PubMed PMID: 23320752

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

View credentials →CAS Number214047-00-4Molecular Weight802.05 g/molPurity≥98%Physical FormLyophilised PowderManufacturingManufactured in an ISO9001 Certified LaboratoryTestingHPLC + MS-UPLCSKURSC-MATRIXYL-5135

Lyophilised powder: store at -20 °C or below, away from light and moisture. Once reconstituted in an appropriate laboratory diluent (e.g. sterile water, PBS, or assay buffer), store at 2–8 °C and use within the validated period for your protocol. Do not refreeze.

Matrixyl (CAS 214047-00-4), also known as Palmitoyl Pentapeptide-4 or Pal-KTTKS, is a synthetic lipopeptide with a molecular weight of 802.06 g/mol. Its structure consists of the pentapeptide sequence Lys-Thr-Thr-Lys-Ser, corresponding to a fragment of type I procollagen, conjugated to a palmitoyl (C16 fatty acid) chain at the N-terminus. The KTTKS sequence was identified through systematic screening of procollagen-derived peptide fragments as a matrikine, a small peptide derived from extracellular matrix proteins that signals back to cells to modulate matrix biology. Produced via solid-phase peptide synthesis with subsequent N-terminal palmitoylation, Matrixyl is associated with collagen biosynthesis and dermal matrix remodelling pathways in preclinical dermatological research.

Matrixyl is one of the most studied matrikine-based lipopeptides in preclinical and cosmeceutical dermatology research. In vitro studies have documented that the parent KTTKS pentapeptide stimulates the production of collagen (types I and III) and fibronectin in cultured fibroblasts, establishing the sequence as a matrikine signal for extracellular matrix synthesis [1]. Structure-activity research has examined the role of the palmitoyl chain in cellular interaction and the contribution of the lipid modification to the compound’s observed activity in cell culture models, documenting that the palmitoylated peptide amphiphile C16-KTTKS self-assembles into nanotape structures and stimulates collagen synthesis in human dermal fibroblast culture, characterising the lipid-conjugated form of the KTTKS matrikine as the basis for its activity as a topically relevant peptide active [2], making Matrixyl a key reference compound in dermatological and extracellular-matrix research examining lipid-conjugated matrikine peptides and procollagen-derived signal sequences in preclinical models.

Matrixyl is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

References

1Katayama K, Armendariz-Borunda J, Raghow R, Kang AH, Seyer JM. A pentapeptide from type I procollagen promotes extracellular matrix production. J Biol Chem. 1993 May 15;268(14):9941–4. .PubMed PMID: 84867212Jones RR, Castelletto V, Connon CJ, Hamley IW. Collagen stimulating effect of peptide amphiphile C16-KTTKS on human fibroblasts. Mol Pharm. 2013 Mar 4;10(3):1063–9. .PubMed PMID: 23320752

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

View credentials →CAS Number214047-00-4Molecular Weight802.05 g/molPurity≥98%Physical FormLyophilised PowderManufacturingManufactured in an ISO9001 Certified LaboratoryTestingHPLC + MS-UPLCSKURSC-MATRIXYL-5135

Lyophilised powder: store at -20 °C or below, away from light and moisture. Once reconstituted in an appropriate laboratory diluent (e.g. sterile water, PBS, or assay buffer), store at 2–8 °C and use within the validated period for your protocol. Do not refreeze.