Buy Thymulin Research Peptide

What is Thymulin?

Thymulin is a natural nine-amino-acid thymus hormone that needs zinc to work and helps guide immune-cell development. Its levels fall with age as the thymus shrinks, and it is studied in animal research for its effects on immune-cell development and immune signaling.

• A nine-amino-acid thymus hormone that requires zinc to be active
• Made by thymus cells; levels decline with age as the thymus shrinks
• Studied in animal research for its effects on T-cell development and cytokine signaling
• Investigated in animal models of age-related immune change

For research use only. Not approved for human therapeutic use.

Thymulin (CAS 63958-90-7), also known as Facteur Thymique Serique (FTS) or Serum Thymic Factor, is a synthetic nonapeptide metallopeptide with a molecular weight of 952.21 g/mol in its zinc-complexed form. Defined by the amino acid sequence pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn, Thymulin features an N-terminal pyroglutamyl residue and requires the coordination of a single zinc ion (Zn2+) for biological activity, a structural requirement that distinguishes it from other thymic peptides. This zinc dependency makes Thymulin one of the few naturally occurring metallopeptide hormones in the endocrine system. Produced via solid-phase peptide synthesis, Thymulin is associated with T-cell differentiation and thymic endocrine signalling.

Thymulin is a thymic hormone whose circulating concentrations correlate with zinc status in experimental models. In vitro studies have examined the zinc-dependent conformational transition underlying Thymulin activity, with research documenting that chelation of metal ions abolishes the biological activity of the serum thymic factor and that zinc restores it, establishing it at the required 1:1 metal-to-peptide molar ratio and forming the basis for the designation of the zinc-complexed form as “thymulin” [1]. In vivo rodent studies have examined circulating Thymulin concentrations in relation to zinc status, thymic involution, and age-related immune function changes, with published research documenting that oral zinc supplementation in aged mice restores active (zinc-saturated) thymulin, induces thymic regrowth, and partially restores peripheral immune function, and characterising the age-related decline as a defect in the zinc saturation of thymulin rather than in its synthesis or secretion [2], making Thymulin a reference compound in thymic peptide research examining the interplay between zinc coordination, metallopeptide hormone activity, and age-related thymic endocrine function.

Thymulin is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

References

1Dardenne M, Pléau JM, Nabarra B, Lefrancier P, Derrien M, Choay J, et al. Contribution of zinc and other metals to the biological activity of the serum thymic factor. Proc Natl Acad Sci U S A. 1982 Sep;79(17):5370–3. ; PubMed Central PMCID: PMC346898.PubMed PMID: 69578702Mocchegiani E, Santarelli L, Muzzioli M, Fabris N. Reversibility of the thymic involution and of age-related peripheral immune dysfunctions by zinc supplementation in old mice. Int J Immunopharmacol. 1995 Sep;17(9):703–18. .PubMed PMID: 8582782

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

View credentials →

Thymulin (CAS 63958-90-7), also known as Facteur Thymique Serique (FTS) or Serum Thymic Factor, is a synthetic nonapeptide metallopeptide with a molecular weight of 952.21 g/mol in its zinc-complexed form. Defined by the amino acid sequence pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn, Thymulin features an N-terminal pyroglutamyl residue and requires the coordination of a single zinc ion (Zn2+) for biological activity, a structural requirement that distinguishes it from other thymic peptides. This zinc dependency makes Thymulin one of the few naturally occurring metallopeptide hormones in the endocrine system. Produced via solid-phase peptide synthesis, Thymulin is associated with T-cell differentiation and thymic endocrine signalling.

Thymulin is a thymic hormone whose circulating concentrations correlate with zinc status in experimental models. In vitro studies have examined the zinc-dependent conformational transition underlying Thymulin activity, with research documenting that chelation of metal ions abolishes the biological activity of the serum thymic factor and that zinc restores it, establishing it at the required 1:1 metal-to-peptide molar ratio and forming the basis for the designation of the zinc-complexed form as “thymulin” [1]. In vivo rodent studies have examined circulating Thymulin concentrations in relation to zinc status, thymic involution, and age-related immune function changes, with published research documenting that oral zinc supplementation in aged mice restores active (zinc-saturated) thymulin, induces thymic regrowth, and partially restores peripheral immune function, and characterising the age-related decline as a defect in the zinc saturation of thymulin rather than in its synthesis or secretion [2], making Thymulin a reference compound in thymic peptide research examining the interplay between zinc coordination, metallopeptide hormone activity, and age-related thymic endocrine function.

Thymulin is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

References

1Dardenne M, Pléau JM, Nabarra B, Lefrancier P, Derrien M, Choay J, et al. Contribution of zinc and other metals to the biological activity of the serum thymic factor. Proc Natl Acad Sci U S A. 1982 Sep;79(17):5370–3. ; PubMed Central PMCID: PMC346898.PubMed PMID: 69578702Mocchegiani E, Santarelli L, Muzzioli M, Fabris N. Reversibility of the thymic involution and of age-related peripheral immune dysfunctions by zinc supplementation in old mice. Int J Immunopharmacol. 1995 Sep;17(9):703–18. .PubMed PMID: 8582782

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

View credentials →CAS Number63958-90-7Molecular Weight858.86 g/molPurity≥98%Physical FormLyophilised PowderManufacturingManufactured in an ISO9001 Certified LaboratoryTestingHPLC + MS-UPLCSKUTHYM

Lyophilised powder: store at -20 °C or below, away from light and moisture. Once reconstituted in an appropriate laboratory diluent (e.g. sterile water, PBS, or assay buffer), store at 2–8 °C and use within the validated period for your protocol. Do not refreeze.

Thymulin (CAS 63958-90-7), also known as Facteur Thymique Serique (FTS) or Serum Thymic Factor, is a synthetic nonapeptide metallopeptide with a molecular weight of 952.21 g/mol in its zinc-complexed form. Defined by the amino acid sequence pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn, Thymulin features an N-terminal pyroglutamyl residue and requires the coordination of a single zinc ion (Zn2+) for biological activity, a structural requirement that distinguishes it from other thymic peptides. This zinc dependency makes Thymulin one of the few naturally occurring metallopeptide hormones in the endocrine system. Produced via solid-phase peptide synthesis, Thymulin is associated with T-cell differentiation and thymic endocrine signalling.

Thymulin is a thymic hormone whose circulating concentrations correlate with zinc status in experimental models. In vitro studies have examined the zinc-dependent conformational transition underlying Thymulin activity, with research documenting that chelation of metal ions abolishes the biological activity of the serum thymic factor and that zinc restores it, establishing it at the required 1:1 metal-to-peptide molar ratio and forming the basis for the designation of the zinc-complexed form as “thymulin” [1]. In vivo rodent studies have examined circulating Thymulin concentrations in relation to zinc status, thymic involution, and age-related immune function changes, with published research documenting that oral zinc supplementation in aged mice restores active (zinc-saturated) thymulin, induces thymic regrowth, and partially restores peripheral immune function, and characterising the age-related decline as a defect in the zinc saturation of thymulin rather than in its synthesis or secretion [2], making Thymulin a reference compound in thymic peptide research examining the interplay between zinc coordination, metallopeptide hormone activity, and age-related thymic endocrine function.

Thymulin is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

References

1Dardenne M, Pléau JM, Nabarra B, Lefrancier P, Derrien M, Choay J, et al. Contribution of zinc and other metals to the biological activity of the serum thymic factor. Proc Natl Acad Sci U S A. 1982 Sep;79(17):5370–3. ; PubMed Central PMCID: PMC346898.PubMed PMID: 69578702Mocchegiani E, Santarelli L, Muzzioli M, Fabris N. Reversibility of the thymic involution and of age-related peripheral immune dysfunctions by zinc supplementation in old mice. Int J Immunopharmacol. 1995 Sep;17(9):703–18. .PubMed PMID: 8582782

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

View credentials →CAS Number63958-90-7Molecular Weight858.86 g/molPurity≥98%Physical FormLyophilised PowderManufacturingManufactured in an ISO9001 Certified LaboratoryTestingHPLC + MS-UPLCSKUTHYM

Lyophilised powder: store at -20 °C or below, away from light and moisture. Once reconstituted in an appropriate laboratory diluent (e.g. sterile water, PBS, or assay buffer), store at 2–8 °C and use within the validated period for your protocol. Do not refreeze.