Buy ADAMAX Research Peptide

What is ADAMAX?

Adamax is a synthetic peptide related to the Semax family of brain-active research compounds, modified to last longer before the body breaks it down. It is studied in animal research for its effects on brain and stress-response signaling.

• A synthetic relative of the Semax family of brain-active research peptides
• Studied in animal research for its effects on brain signaling and the stress response
• Modified to resist breakdown so it stays active longer in research models
• Investigated alongside Semax and related compounds in brain research

For research use only. Not approved for human therapeutic use.

ADAMAX, formally designated N-Acetyl Semax-Adamantane, is a synthetic nonapeptide and designer analogue of Semax incorporating two pharmacokinetically significant terminal modifications. With the molecular formula C50H69N11O11S and a molecular weight of 1032.23 g/mol, ADAMAX retains the ACTH(4-7)-PGP core sequence of Semax but adds an N-terminal acetyl group and a C-terminal adamantane (tricyclic diamondoid) moiety. The acetyl modification confers resistance to N-terminal aminopeptidase degradation, while the adamantane group, a rigid and highly lipophilic hydrocarbon cage, is considered relevant to metabolic stability and membrane permeability. Produced via solid-phase peptide synthesis, ADAMAX is associated with neurotrophic factor signalling.

ADAMAX has been investigated in preclinical neurobiology as a structurally optimised Semax derivative, with its dual terminal modifications representing a deliberate approach to extending peptide half-life and altering pharmacokinetic properties. The adamantane motif, characterised in medicinal chemistry as a lipophilicity-increasing scaffold, has been incorporated to address the known susceptibility of melanocortin-derived peptides to rapid enzymatic degradation. In vitro studies have examined BDNF and neurotrophic factor expression in the context of the ACTH(4-7)-PGP pharmacological profile, with research documenting Semax-mediated activation of BDNF and NGF expression in rat basal forebrain tissue preparations and characterising neurotrophic factor induction as a defined signalling output of the ACTH(4-7)-PGP core [1][2],making ADAMAX a reference compound in melanocortin-derived neuropeptide research examining structurally optimised analogues of the ACTH(4-7)-PGP scaffold. Preclinical pharmacokinetic studies have investigated the penetration of Semax/ACTH(4–7)-PGP into rat blood and brain after intranasal administration, while comparative degradation studies indicate that Semax is more stable than native ACTH(4–10) against rat blood enzymes [3].

ADAMAX is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

References

1Dolotov OV, Karpenko EA, Seredenina TS, Inozemtseva LS, Levitskaya NG, Zolotarev YA, et al. Semax, an analogue of adrenocorticotropin (4–10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain. Journal of Neurochemistry. 2006;97(s1):82–6.doi:10.1111/j.1471-4159.2006.03658.x2Shadrina MI, Dolotov OV, Grivennikov IA, Slominsky PA, Andreeva LA, Inozemtseva LS, et al. Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Semax, an adrenocorticotropic hormone analog. Neurosci Lett. 2001 Aug 3;308(2):115–8. .PubMed PMID: 114575733Shevchenko KV, Nagaev II, Alfeeva LI, Andreeva LA, Kamenskiĭ AA, Levitskaia NG, et al. [Kinetics of Semax penetration into the brain and blood of rats after its intranasal administration]. Bioorg Khim. 2006;32(1):64–70. .PubMed PMID: 16523722

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

View credentials →

ADAMAX, formally designated N-Acetyl Semax-Adamantane, is a synthetic nonapeptide and designer analogue of Semax incorporating two pharmacokinetically significant terminal modifications. With the molecular formula C50H69N11O11S and a molecular weight of 1032.23 g/mol, ADAMAX retains the ACTH(4-7)-PGP core sequence of Semax but adds an N-terminal acetyl group and a C-terminal adamantane (tricyclic diamondoid) moiety. The acetyl modification confers resistance to N-terminal aminopeptidase degradation, while the adamantane group, a rigid and highly lipophilic hydrocarbon cage, is considered relevant to metabolic stability and membrane permeability. Produced via solid-phase peptide synthesis, ADAMAX is associated with neurotrophic factor signalling.

ADAMAX has been investigated in preclinical neurobiology as a structurally optimised Semax derivative, with its dual terminal modifications representing a deliberate approach to extending peptide half-life and altering pharmacokinetic properties. The adamantane motif, characterised in medicinal chemistry as a lipophilicity-increasing scaffold, has been incorporated to address the known susceptibility of melanocortin-derived peptides to rapid enzymatic degradation. In vitro studies have examined BDNF and neurotrophic factor expression in the context of the ACTH(4-7)-PGP pharmacological profile, with research documenting Semax-mediated activation of BDNF and NGF expression in rat basal forebrain tissue preparations and characterising neurotrophic factor induction as a defined signalling output of the ACTH(4-7)-PGP core [1][2],making ADAMAX a reference compound in melanocortin-derived neuropeptide research examining structurally optimised analogues of the ACTH(4-7)-PGP scaffold. Preclinical pharmacokinetic studies have investigated the penetration of Semax/ACTH(4–7)-PGP into rat blood and brain after intranasal administration, while comparative degradation studies indicate that Semax is more stable than native ACTH(4–10) against rat blood enzymes [3].

ADAMAX is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

References

1Dolotov OV, Karpenko EA, Seredenina TS, Inozemtseva LS, Levitskaya NG, Zolotarev YA, et al. Semax, an analogue of adrenocorticotropin (4–10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain. Journal of Neurochemistry. 2006;97(s1):82–6.doi:10.1111/j.1471-4159.2006.03658.x2Shadrina MI, Dolotov OV, Grivennikov IA, Slominsky PA, Andreeva LA, Inozemtseva LS, et al. Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Semax, an adrenocorticotropic hormone analog. Neurosci Lett. 2001 Aug 3;308(2):115–8. .PubMed PMID: 114575733Shevchenko KV, Nagaev II, Alfeeva LI, Andreeva LA, Kamenskiĭ AA, Levitskaia NG, et al. [Kinetics of Semax penetration into the brain and blood of rats after its intranasal administration]. Bioorg Khim. 2006;32(1):64–70. .PubMed PMID: 16523722

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

View credentials →CAS Number114681-65-1Molecular Weight1,032.24 g/molPurity≥98%Physical FormLyophilised PowderManufacturingManufactured in an ISO9001 Certified LaboratoryTestingHPLC + MS-UPLCSKURSC-ADAMAX-8420

Lyophilised powder: store at -20 °C or below, away from light and moisture. Once reconstituted in an appropriate laboratory diluent (e.g. sterile water, PBS, or assay buffer), store at 2–8 °C and use within the validated period for your protocol. Do not refreeze.

ADAMAX, formally designated N-Acetyl Semax-Adamantane, is a synthetic nonapeptide and designer analogue of Semax incorporating two pharmacokinetically significant terminal modifications. With the molecular formula C50H69N11O11S and a molecular weight of 1032.23 g/mol, ADAMAX retains the ACTH(4-7)-PGP core sequence of Semax but adds an N-terminal acetyl group and a C-terminal adamantane (tricyclic diamondoid) moiety. The acetyl modification confers resistance to N-terminal aminopeptidase degradation, while the adamantane group, a rigid and highly lipophilic hydrocarbon cage, is considered relevant to metabolic stability and membrane permeability. Produced via solid-phase peptide synthesis, ADAMAX is associated with neurotrophic factor signalling.

ADAMAX has been investigated in preclinical neurobiology as a structurally optimised Semax derivative, with its dual terminal modifications representing a deliberate approach to extending peptide half-life and altering pharmacokinetic properties. The adamantane motif, characterised in medicinal chemistry as a lipophilicity-increasing scaffold, has been incorporated to address the known susceptibility of melanocortin-derived peptides to rapid enzymatic degradation. In vitro studies have examined BDNF and neurotrophic factor expression in the context of the ACTH(4-7)-PGP pharmacological profile, with research documenting Semax-mediated activation of BDNF and NGF expression in rat basal forebrain tissue preparations and characterising neurotrophic factor induction as a defined signalling output of the ACTH(4-7)-PGP core [1][2],making ADAMAX a reference compound in melanocortin-derived neuropeptide research examining structurally optimised analogues of the ACTH(4-7)-PGP scaffold. Preclinical pharmacokinetic studies have investigated the penetration of Semax/ACTH(4–7)-PGP into rat blood and brain after intranasal administration, while comparative degradation studies indicate that Semax is more stable than native ACTH(4–10) against rat blood enzymes [3].

ADAMAX is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

References

1Dolotov OV, Karpenko EA, Seredenina TS, Inozemtseva LS, Levitskaya NG, Zolotarev YA, et al. Semax, an analogue of adrenocorticotropin (4–10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain. Journal of Neurochemistry. 2006;97(s1):82–6.doi:10.1111/j.1471-4159.2006.03658.x2Shadrina MI, Dolotov OV, Grivennikov IA, Slominsky PA, Andreeva LA, Inozemtseva LS, et al. Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Semax, an adrenocorticotropic hormone analog. Neurosci Lett. 2001 Aug 3;308(2):115–8. .PubMed PMID: 114575733Shevchenko KV, Nagaev II, Alfeeva LI, Andreeva LA, Kamenskiĭ AA, Levitskaia NG, et al. [Kinetics of Semax penetration into the brain and blood of rats after its intranasal administration]. Bioorg Khim. 2006;32(1):64–70. .PubMed PMID: 16523722

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

View credentials →CAS Number114681-65-1Molecular Weight1,032.24 g/molPurity≥98%Physical FormLyophilised PowderManufacturingManufactured in an ISO9001 Certified LaboratoryTestingHPLC + MS-UPLCSKURSC-ADAMAX-8420

Lyophilised powder: store at -20 °C or below, away from light and moisture. Once reconstituted in an appropriate laboratory diluent (e.g. sterile water, PBS, or assay buffer), store at 2–8 °C and use within the validated period for your protocol. Do not refreeze.