Buy Selank Research Peptide

What is Selank?

Selank is a synthetic seven-amino-acid peptide based on the natural immune peptide tuftsin, developed in Russia. It is studied in animal research for its effects on calming (GABA) brain signaling and the stress-response system.

• A seven-amino-acid analog of the natural peptide tuftsin
• Studied in animal research for its effects on calming (GABA) brain signaling
• Investigated for its effects on stress-related neurotransmitter signaling in animal models
• Also studied for its effects on BDNF and nerve-growth signaling

For research use only. Not approved for human therapeutic use.

Selank (CAS 129954-34-3), also known by its developmental code TP-7, is a synthetic heptapeptide and structural analogue of the naturally occurring immunomodulatory tetrapeptide tuftsin. With the molecular formula C33H57N11O9 and a molecular weight of 751.88 g/mol, Selank is defined by the amino acid sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro, incorporating the tuftsin core (Thr-Lys-Pro-Arg) extended at the C-terminus with a Pro-Gly-Pro stabilising motif. This structural feature is considered relevant to its resistance to proteolytic degradation.

Produced via solid-phase peptide synthesis, TP-7 is associated with GABAergic and monoaminergic signalling pathways in preclinical neuroscience and immunology research.

Selank has been investigated in preclinical research across both neuroactive and immunomodulatory contexts, a profile that reflects its structural derivation from tuftsin, a fragment of immunoglobulin G (IgG) associated with innate immune signalling. Its C-terminal Pro-Gly-Pro extension has been characterised in published structure-activity studies as relevant to central nervous system accessibility and peptide stability. In vitro electrophysiology studies in rat hippocampal CA1 pyramidal neuron preparations have examined Selank’s modulation of spontaneous inhibitory postsynaptic currents, documenting increased GABAergic inhibitory neurotransmission through increases in both amplitude and discharge frequency of spontaneous IPSCs and characterising this GABAergic modulatory profile as a neurophysiological basis of TP-7’s neuroactive properties [1]. In vivo rodent behavioural pharmacology studies have examined TP-7 alongside cytokine expression profiling, documenting that Selank administration modulates pro-inflammatory cytokine under social conflict stress conditions in rodents, characterising the relationship between immunomodulatory peptide signalling and central immune marker dynamics under acute stress challenge [2], making Selank a key reference compound in research examining the intersection of GABAergic neuropharmacology and immunomodulatory peptide signalling.

Selank is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

References

1Povarov IS, Kondratenko RV, Derevyagin VI, Myasoedov NF, Skrebitsky VG. Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons. Bull Exp Biol Med. 2017 Mar;162(5):640–2. .PubMed PMID: 283614102Leonidovna YA, Aleksandrovna SM, Aleksandrovna TA, Aleksandrovna BO, Fedorovich MN, Aleksandrovna AL. The Influence of Selank on the Level of Cytokines Under the Conditions of “Social” Stress. Curr Rev Clin Exp Pharmacol. 2021;16(2):162–7. .PubMed PMID: 32621722

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

View credentials →

Selank (CAS 129954-34-3), also known by its developmental code TP-7, is a synthetic heptapeptide and structural analogue of the naturally occurring immunomodulatory tetrapeptide tuftsin. With the molecular formula C33H57N11O9 and a molecular weight of 751.88 g/mol, Selank is defined by the amino acid sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro, incorporating the tuftsin core (Thr-Lys-Pro-Arg) extended at the C-terminus with a Pro-Gly-Pro stabilising motif. This structural feature is considered relevant to its resistance to proteolytic degradation.

Produced via solid-phase peptide synthesis, TP-7 is associated with GABAergic and monoaminergic signalling pathways in preclinical neuroscience and immunology research.

Selank has been investigated in preclinical research across both neuroactive and immunomodulatory contexts, a profile that reflects its structural derivation from tuftsin, a fragment of immunoglobulin G (IgG) associated with innate immune signalling. Its C-terminal Pro-Gly-Pro extension has been characterised in published structure-activity studies as relevant to central nervous system accessibility and peptide stability. In vitro electrophysiology studies in rat hippocampal CA1 pyramidal neuron preparations have examined Selank’s modulation of spontaneous inhibitory postsynaptic currents, documenting increased GABAergic inhibitory neurotransmission through increases in both amplitude and discharge frequency of spontaneous IPSCs and characterising this GABAergic modulatory profile as a neurophysiological basis of TP-7’s neuroactive properties [1]. In vivo rodent behavioural pharmacology studies have examined TP-7 alongside cytokine expression profiling, documenting that Selank administration modulates pro-inflammatory cytokine under social conflict stress conditions in rodents, characterising the relationship between immunomodulatory peptide signalling and central immune marker dynamics under acute stress challenge [2], making Selank a key reference compound in research examining the intersection of GABAergic neuropharmacology and immunomodulatory peptide signalling.

Selank is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

References

1Povarov IS, Kondratenko RV, Derevyagin VI, Myasoedov NF, Skrebitsky VG. Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons. Bull Exp Biol Med. 2017 Mar;162(5):640–2. .PubMed PMID: 283614102Leonidovna YA, Aleksandrovna SM, Aleksandrovna TA, Aleksandrovna BO, Fedorovich MN, Aleksandrovna AL. The Influence of Selank on the Level of Cytokines Under the Conditions of “Social” Stress. Curr Rev Clin Exp Pharmacol. 2021;16(2):162–7. .PubMed PMID: 32621722

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

View credentials →CAS Number129954-34-3Molecular Weight751.88 g/molPurity≥98%Physical FormLyophilised PowderManufacturingManufactured in an ISO9001 Certified LaboratoryTestingHPLC + MS-UPLCSKUSEL

Lyophilised powder: store at -20 °C or below, away from light and moisture. Once reconstituted in an appropriate laboratory diluent (e.g. sterile water, PBS, or assay buffer), store at 2–8 °C and use within the validated period for your protocol. Do not refreeze.

Selank (CAS 129954-34-3), also known by its developmental code TP-7, is a synthetic heptapeptide and structural analogue of the naturally occurring immunomodulatory tetrapeptide tuftsin. With the molecular formula C33H57N11O9 and a molecular weight of 751.88 g/mol, Selank is defined by the amino acid sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro, incorporating the tuftsin core (Thr-Lys-Pro-Arg) extended at the C-terminus with a Pro-Gly-Pro stabilising motif. This structural feature is considered relevant to its resistance to proteolytic degradation.

Produced via solid-phase peptide synthesis, TP-7 is associated with GABAergic and monoaminergic signalling pathways in preclinical neuroscience and immunology research.

Selank has been investigated in preclinical research across both neuroactive and immunomodulatory contexts, a profile that reflects its structural derivation from tuftsin, a fragment of immunoglobulin G (IgG) associated with innate immune signalling. Its C-terminal Pro-Gly-Pro extension has been characterised in published structure-activity studies as relevant to central nervous system accessibility and peptide stability. In vitro electrophysiology studies in rat hippocampal CA1 pyramidal neuron preparations have examined Selank’s modulation of spontaneous inhibitory postsynaptic currents, documenting increased GABAergic inhibitory neurotransmission through increases in both amplitude and discharge frequency of spontaneous IPSCs and characterising this GABAergic modulatory profile as a neurophysiological basis of TP-7’s neuroactive properties [1]. In vivo rodent behavioural pharmacology studies have examined TP-7 alongside cytokine expression profiling, documenting that Selank administration modulates pro-inflammatory cytokine under social conflict stress conditions in rodents, characterising the relationship between immunomodulatory peptide signalling and central immune marker dynamics under acute stress challenge [2], making Selank a key reference compound in research examining the intersection of GABAergic neuropharmacology and immunomodulatory peptide signalling.

Selank is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

References

1Povarov IS, Kondratenko RV, Derevyagin VI, Myasoedov NF, Skrebitsky VG. Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons. Bull Exp Biol Med. 2017 Mar;162(5):640–2. .PubMed PMID: 283614102Leonidovna YA, Aleksandrovna SM, Aleksandrovna TA, Aleksandrovna BO, Fedorovich MN, Aleksandrovna AL. The Influence of Selank on the Level of Cytokines Under the Conditions of “Social” Stress. Curr Rev Clin Exp Pharmacol. 2021;16(2):162–7. .PubMed PMID: 32621722

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

View credentials →CAS Number129954-34-3Molecular Weight751.88 g/molPurity≥98%Physical FormLyophilised PowderManufacturingManufactured in an ISO9001 Certified LaboratoryTestingHPLC + MS-UPLCSKUSEL

Lyophilised powder: store at -20 °C or below, away from light and moisture. Once reconstituted in an appropriate laboratory diluent (e.g. sterile water, PBS, or assay buffer), store at 2–8 °C and use within the validated period for your protocol. Do not refreeze.